IDENTIFICATION OF ENDOCRINE-DISRUPTING CHEMICALS TARGETING KEY OP-ASSOCIATED GENES VIA BIOINFORMATICS AND MACHINE LEARNING

Identification of endocrine-disrupting chemicals targeting key OP-associated genes via bioinformatics and machine learning

Osteoporosis (OP), a metabolic disorder predominantly impacting postmenopausal women, has seen considerable progress in diagnosis and treatment over the past few decades.However, the intricate interplay between genetic factors and endocrine disruptors (EDCs) in the pathogenesis of OP Glitter remains inadequately elucidated.The objective of this res

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Determination of three ultraviolet filters in sunscreen formulations and from skin penetration studies by high-performance liquid chromatography

An analytical procedure to quantify 3-benzophenone, octylmethoxycinnamate and octylsalicylate was validated and employed to assess these ultraviolet filters in sunscreen formulations and from skin penetration studies.The effect of the vehicle Parts on the skin retention of these filters was investigated.HPLC and extraction procedure were found to b

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Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach

Abstract The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well established.Early in the course of the diabetic disease, some degree of impaired exercise capacity (a powerful marker of health status with prognostic value) can be frequently highlighted in otherwise asymptomatic T2DM subjects.However, the literature is

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Tank mixtures of insecticides and fungicides, adjuvants, additives, fertilizers and their effects on honey bees after contact exposure in a spray chamber

In agriculture honey bees may be exposed to multiple pesticides.In contrast to single applications of plant protection products (PPP), the effects of tank mixtures of two or more PPP on honey bees are not routinely assessed in the risk assessment of plant protection products.However, tank mixes are often common practice by farmers.Mixtures of pract

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